Nanopicture of the Day

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January 6, 2004

Biomedical Magnetic Nanoparticles

Source: Catherine Berry

      References:

Berry CC, Curtis ASG. "Functionalisation of magnetic nanoparticles for applications in biomedicine" JOURNAL OF PHYSICS D-APPLIED PHYSICS 36 (13): R198-R206 JUL 7 2003

Berry CC, Wells S, Charles S, et al.  "Dextran and albumin derivatised iron oxide nanoparticles: influence on fibroblasts in vitro."  BIOMATERIALS. 24 (25): 4551-4557 NOV 2003.
 

Description:

Nano-biotechnologies are being expanded to include the development of magnetic nanoparticles for clinical applications. The use of magnetic nanoparticles in biomedical applications has been proposed for many years.  In recent years, nanotechnology has developed to a stage that makes it possible to produce, characterize and specifically tailor the functional properties of nanoparticles for clinical applications. This has led to various opportunities such as improving the quality of magnetic resonance imaging, hyperthermic treatment for malignant cells, site-specific drug delivery and the manipulation of cell membranes.

A powerful research tool is observation of a cell cytoskeleton, which allows us to determine cell motility, and gauge the cells metabolic state. The image above shows a human fibroblasts actin (red) and tubulin (green) cytoskeleton in response to magnetic nano-particles (nucleus is stained blue).

 

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