Description:

Mast cells are specialty cells that trigger immuno-responses, such as the release of histamine, when an allergen is encountered. Thorough understanding of the complicated motions of receptors and other cell surface components sheds light on the complex cascades of antibody- receptor signal transduction on these cell surfaces.

These non-random diffusion motions can be followed via a quantitative microscopy technique called Single Particle Tracking.  Single particle tracking (SPT) provides a detailed view of cell surface dynamics by imaging individual trajectories of labeled protein or lipid molecules.  This gives insight into the specific function of the biomolecules in the cell's functioning.

 

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