Nanopicture of the Day

www.nanopicoftheday.org

December 23, 2003

Heart

Source: Todd McDevitt, et. al.

      References:

McDevitt,TC; Angello,JC; Whitney,ML; Reinecke,H; Hauschka,SD; Murry,CE; Stayton,PS "In vitro generation of differentiated cardiac myofibers on micropatterned laminin surfaces." J. Biomed. Mater. Res. 60, 472-479. (2002)
 

Additional Related References:

 

Ratner, B.D. "New ideas in biomaterials science: a path to engineered biomaterials". J. Biomed. Mater. Res. 27:837-850, 1993.
 

Ratner, B.D. "The blood compatibility catastrophe." J. Biomed. Mater. Res. 27:283-287, 1993.

Description:

It's currently possible to grow cardiac cells in the laboratory, but the result is random and disordered. To be useful, the cells must be organized so they can work together as functioning tissue.  University of Washington researchers are finding ways to organize cultured cardiac cells. By placing adhesive proteins on a grid, they've prompted the heart cells to line up, resulting in cardiac fibers similar to those found in natural heart tissue. Scientists will build upon such preliminary research in the UW's new tissue-engineered heart project.

 

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